MovDisordV3, France, Analysis, bibRecord, 000618

Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease

Identifieur interne : 000618 ( France/Analysis ); précédent : 000617; suivant : 000619

Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease

Auteurs : Rascol [France] ; U. Sabatini [Italie] ; N. Fabre [France] ; J. M. Senard [France] ; M. Simonetta-Moreau [France] ; J. L. Montastruc [France] ; M. Clanet [France] ; A. Rascol [France]

Source :

Movement Disorders [ 0885-3185 ] ; 1995-03.

RBID : ISTEX:60C7E4DF9958BAD417EDF66D394BBED809729258

English descriptors

KwdEn :
- Age Factors, Aged, Atrophy (diagnosis), Atrophy (physiopathology), Brain (pathology), Cerebral Palsy (diagnosis), Cerebral Palsy (physiopathology), Diagnosis, Differential, Humans, Middle Aged, Multiple system atrophy, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson's disease, Reflex, Vestibulo-Ocular, Supranuclear palsy, Vestibuloocular reflex cancellation.
MESH :
- diagnosis : Atrophy, Cerebral Palsy, Parkinson Disease.
- pathology : Brain.
- physiopathology : Atrophy, Cerebral Palsy, Parkinson Disease.
- Age Factors, Aged, Diagnosis, Differential, Humans, Middle Aged, Reflex, Vestibulo-Ocular.

Abstract

We have measured the gain of the vestibuloocular reflex (VOR) in darkness and its cancellation by fixation in 37 patients with Parkinson's disease (PD), 26 patients with multiple system atrophy (MSA), 11 patients with progressive supranuclear palsy (PSP), and 19 normal volunteers. The capacity to cancel the VOR by fixation (VOR cancellation) was significantly reduced in the MSA and PSP patients compared with the PD and normal subjects (p < 10−4). A VOR cancellation < 90% (i.e., the mean VOR cancellation of the normals ‐ 2 SD) was present in four PD patients, 23 MSA patients, and 11 PSP patients. This criteria distinguished PD and MSA with a 89% sensitivity and a 89% specificity. Our results demonstrate that the VOR cancellation is impaired in most patients with MSA and PSP but not with PD. In MSA patients, the abnormal VOR cancellation is probably not related to the nigrostriatal dopaminergic deficit and more likely reflects a cerebellar dysfunction. Impaired VOR cancellation is a clinical criteria to differentiate MSA and PSP from PD.

Url:

https://api.istex.fr/document/60C7E4DF9958BAD417EDF66D394BBED809729258/fulltext/pdf

DOI: 10.1002/mds.870100206

Affiliations:

Links to Exploration step

ISTEX:60C7E4DF9958BAD417EDF66D394BBED809729258

Le document en format XML

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<author><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">Rascol</name>
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<author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name>
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<author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N." last="Fabre">N. Fabre</name>
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<author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J. M." last="Senard">J. M. Senard</name>
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<author><name sortKey="Simonetta Oreau, M" sort="Simonetta Oreau, M" uniqKey="Simonetta Oreau M" first="M." last="Simonetta-Moreau">M. Simonetta-Moreau</name>
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<author><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M." last="Clanet">M. Clanet</name>
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<front><div type="abstract" xml:lang="en">We have measured the gain of the vestibuloocular reflex (VOR) in darkness and its cancellation by fixation in 37 patients with Parkinson's disease (PD), 26 patients with multiple system atrophy (MSA), 11 patients with progressive supranuclear palsy (PSP), and 19 normal volunteers. The capacity to cancel the VOR by fixation (VOR cancellation) was significantly reduced in the MSA and PSP patients compared with the PD and normal subjects (p < 10−4). A VOR cancellation < 90% (i.e., the mean VOR cancellation of the normals ‐ 2 SD) was present in four PD patients, 23 MSA patients, and 11 PSP patients. This criteria distinguished PD and MSA with a 89% sensitivity and a 89% specificity. Our results demonstrate that the VOR cancellation is impaired in most patients with MSA and PSP but not with PD. In MSA patients, the abnormal VOR cancellation is probably not related to the nigrostriatal dopaminergic deficit and more likely reflects a cerebellar dysfunction. Impaired VOR cancellation is a clinical criteria to differentiate MSA and PSP from PD.</div>
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Movement Disorders (revue)

Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease

Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease

Source :

English descriptors

Abstract

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Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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